Abstarct: Background and Objective: Methamphetamine is a powerful stimulant of the central nervous system. Abuse of methamphetamine can cause irreversible damage to brain cells. Considering the positive effects of exercise on the functioning of the nervous system, as well as its role in creating neuroprotection and resistance to brain damage, the present study investigates the effect of four weeks of psilocybin induction and aerobic exercise on the balance and tissue structure of methamphetamine-addicted rats. Materials and Methods :30 female Wistar rats were selected according to weight and age conditions and divided into 5 groups of 6: 1- healthy control. 2- receiving methamphetamine 3- methamphetamine + aerobic activity 4- methamphetamine + psilocybin 5- methamphetamine + aerobic activity + psilocybin. Intraperitoneal methamphetamine induction at 10 mg and psilocybin induction at 0.025 mg/kg intraperitoneal was considered. The aerobic exercise program included 4 weeks of running on a treadmill at a speed of 25 meters per minute for 30 minutes and 6 days a week in groups addicted to methamphetamine.(p≤0.05). Results: In the group receiving methamphetamine compared to the control group, moderate changes were observed in Purkinje's laxyers and white matter of the cerebellum and mild changes in the molecular laxyer and granular laxyer, and among the available treatment methods, receiving exercise and psilocybin simultaneously is an effective method in reducing the destructive changes caused by The use of methamphetamine in the Purkinje laxyer and receiving psilocybin and exercise separately had the same effect in reducing the destructive changes caused by the use of methamphetamine in the molecular and granular laxyers of the cerebellum (p<0.05). In the balance test, the mice of the addicted control group had a longer slip and duration than the healthy control group, and a significant decrease was found in the psilocybin and exercise group. Conclusion: The above results showed that receiving psilocybin and aerobic exercise during the withdrawal period improves cognitive-motor dysfunction and cerebellar tissue in methamphetamine addicts and does not affect cerebellar tissue changes.